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5-diphenyl-3H-1
HG-7-85-01 Catalog No.:M27807-C 5-diphenyl-3H-1HG 7 85 01 is a type II ATP competitive inhibitor of wild type and gatekeeper mutations forms of Bcr Abl, PDGFR, Kit, and Src kinases. HG 7 85 01 inhibits T315I mutant Bcr Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 M). HG 7 85 01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell cycle progression. Product information CAS
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